Articles by Yumi Sasaki


Exon Skipping Therapy

Duchenne muscular dystrophy (DMD) is a lethal genetic disorder that shortens patients’ lifespans and results in progressive skeletal and cardiac muscle degeneration. The symptoms emerge at the onset of muscle growth in boys 2-5 years old. They grow up bound to wheelchairs and ventilators, and eventually succumb to an early death after cardiac failure (2)….

CAR T-Cell Therapy

Cancer operates stealthily, overtaking body systems via hijacking formerly healthy cells, and propagating endless, devastating effects throughout the body. Until recently, there was slim hope for the body itself to recognize and eliminate the assailant cells. However, with the emergence of chimeric antigen receptor T-cell therapy, or CAR T-cell therapy, cancer’s undoing may be on…

Xenotransplantation and Gene Editing in Pigs

Xenotransplantation, the transplantation, implantation, or infusion into a human recipient from an animal donor, has been attempted for more than 300 years with little to no success [1]. The possibility of an essentially unlimited pool of organs to choose from has taunted many transplant surgeons and researchers alike. Beginning with blood xenotransfusion, then the grafting…

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